Bio-ICT Bioinformatics and Molecular Modelling

Research Activity:
The rapid increase of 3D structures of biological macromolecules available in databases such as the Protein Data Bank (PDB) has led to the development of methodologies for the representation, storage and retrieval, prediction and specific analysis that goes under the name of structural bioinformatics. The application of these methods contributes to the study and investigation of problems in the biological and biomedical field. The aim of this research area is to develop and apply computational methods for the prediction and analysis of protein structures and their variants and to simulate the interaction with ligands in order to define the binding properties of natural and exogenous compounds with pharmacological action or metabolic interference. These studies will be applied to various biological model systems that include proteins involved in cellular degraded pathways and coagulative processes as well as hormone receptors and viral proteins. These studies will be integrated and supported by experimental biochemical, molecular and cellular biological data aimed at the characterization of functional protein systems. The calculation is based on HPC and Grid Computing.

Full title:
Bio-ICT Bioinformatics and Molecular Modelling

Project:
INT.P02 / Bioinformatics

Research Area code:
INT.P02.011 / Bio-ICT Bioinformatics and Molecular Modelling

Research Units:

Molecular Modelling and GRID Computing

Functional genomics and proteomics

Institute responsible for the Research Area:
Institute of Biomedical Technologies (ITB)

Institute repsonisble for the Reserch Unit:

Activity start date:
2007

Forseen end date of activity :
2011

Status:
Proposal for continuation

SIGLA code:
6124