Functional genomics and proteomics

Research themes:

1. Multiproteic complex analysis finalized to protein degradation (misfolded/unproperly folded) via endoplasmatic reticulum (ERAD/UPR process).

2. ERAD/UPR pathway alteration in multiple myelomas and during cell B differentiation.

3. “Cell lines microarray” (CLM) technology used for studing the effect of nanoparticles (Nps) on endoplasmatic reticulum ossidative stress.

4. Immunofenotyping, through Paraffin-Embedded Cell Line Microarrays (CLMA), of cells dervived from multiform glioblastoma and cultivated in vitro to determine the expression and distribution of sub-cellular markers.

Objectives:

1. Define the role of genes and proteins in endocitosis and ubiquitin-proteasome pathways in pre and neoplasmatic cells through biological, molecular and cellular biochemistry techniques.

2. Structural interpretation of associated amino-acidic variants.

Expected results in the year:

1. To understand the role of SEL 1L and HRD 1 protein in the differentiation and maturing of B cells.

2. SEL 1L/HRD 1 involvement analysis in myelomas and plasmacytes.

3. Cell line microarray platform development for immunoistochemistry e immunofluorescence analysis.

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Other Research Units in the Bio-ICT Bioinformatics and Molecular Modelling Research Area:

Molecular Modelling and GRID Computing